Poles have created a new model for ovarian cancer research
Polish scientists have created a new model for preclinical studies of the most common and dangerous type of ovarian cancer. They hope it will help in better understanding of this cancer and in the search for new effective drugs.
Ovarian cancer is the fifth most common cancer in terms of incidenceor withinod women in Poland, according to data from the National Cancer Registryow. Under this term, however, there are many disease entities. The most common and dangerous malignant tumor of the ovary is the so-called “ovarian cancer”. serous carcinoma low inoThe DNA in the. High Grade Serous Ovarian Cancer), whichory accounts for approx. 70 percent of. of all cases ofow.
– Meanwhile, it turns out that – although this very canceror should be headoThe main purpose of our research – there is practically no good model on which to base our researchorym could conduct this research,” states in an interview with PAP Dr. hab. Katarzyna Lisowska of the Oncology Center of the Gliwice branch of the Institute of the. Maria Skłodowska-Curie.
This is because in preclinical cancer research, the key is the so called “cancer of the ovary”. cell linesorkowe: continuously dividing cell culturesorek, selected from a cancer tumor. They are the model on whichoIn this way, scientists learn about the mechanisms that control the development of cancer and test the candidateow for new drugs.
– Most of the comork used today for ovarian cancer research was derived long ago, when it was not yet known that roThe different histological types of this cancer are actually separate disease entities – and therefore it is very important to accurately describe the lineage, explains Prof. Lisowska. Lisowska. – Now it turns out that it is not entirely clear what type of cancer it is derived from, for example. SKOV3, one of the most popular comorkowe – he adds.
Even more important is the fact that the Polish research group, in which theowhich works prof. Lisowska, it has been possible to derive a completely new com lineorkowa low-romercialized serous ovarian cancer. Scientists report on the new line, dubbed OVPA8, in a publication thatora appeared in the journal "International Journal of MolecularSciences".
– ComoWe have been breeding these lines for several years, since 2011. At this point, we already know that this line is immortalized, stabilized, and whoever we send it to will mohead to culture it and do experiments on it – mowi prof. Lisowska.
As he adds, the derivation of the new line of comorkowa is not a simple thing: although Polish scientists had at their disposal material taken from eight patients, they managed to grow only one line.
– Today’s cell culture techniquesorkowe are obviously getting better and better, and it will be easier and easier to derive this type of line, the researcher states. – Ours, however, has an advantage over others: it is already quite well characterized, and further research is underway. KomoThese sources are not "anonymous" – We already know, for example., Where and what mutations occur in them, which in the case of comorek of cancerous tumors is very important information. This line is a roalso quite convenient to work with: it divides quickly and is robust.
Especially this last feature may appeal to other scientists. As Prof. Lisowska, the aforementioned SKOV3 – a popular but poorly described line of comorkowa – is just such a "convenient" line. – It is very good to work with it, because the comorki these rapidly divide and do not have high demands. In turn, the lines, whichore have so far been indicated as better models of low-grade serous carcinoma,” she explainsoof cancer, are "difficult": they do not want to form tumorsow, grow slowly, and die in culture,” the researcher stresses.
In the near future, derived by Polakow line will be transferred to the European Collection of Authenticated Cell Cultures (ECACC), from where it will be made available to interested scientists. – We offer them a new model for preclinical research – better, we hope, than the previous ones – mowi prof. Lisowska. He points out, however, that this will be a real test for the line of. – Such work and such new lines show up from time to time: however, only the release of it in an international collection will verify whether it really is as useful and convenient for work as I convince you,” smiles the researcher.
